货号	规格	价格	上海	北京	珠海	重庆	武汉
S89234-5mg买3赠1	98.70%	￥408.00 S89234-5mg ￥408.00 现货（买3赠1）	4 4	-	-	-	-
S89234-10mg买3赠1	98.70%	￥612.00 S89234-10mg ￥612.00 现货（买3赠1）	6 6	-	-	-	-
S89234-25mg买3赠1	98.70%	￥1090.00 S89234-25mg ￥1090.00 现货（买3赠1）	8 8	-	-	-	-
S89234-100mg买3赠1	98.70%	￥2400.00 S89234-100mg ￥2400.00 现货（买3赠1）	2 2	-	-	-	-

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产品描述：

GSK-LSD1 2HCl is a selective inhibitor of LSD1 with IC50 value of 16 nM . Lysine (K) -specific demethylase 1A (LSD1) is a flavin-dependent histone demethylase that demethylates mono- and di-methylated lysines and plays an important role in oocyte growth, embryogenesis and tissue-specific differentiation. LSD1 plays a role in acute myeloid leukemia (AML). GSK-LSD1 2HCl irreversibly inhibited LSD1 with IC50 value of 16 nM and is > 1000 fold selective over LSD2, MAO-A and MAO-B, which were related to FAD utilizing enzymes. In cancer cell lines, GSK-LSD1 2HCl changed gene expression with average EC50 value < 5 nM and inhibited cells growth with average EC50 value < 5 nM. GSK-LSD1 2HCl (10 ?M) inhibited human recombinant dopamine transporter, 5-HT1A and 5-HT transporter by 39%, 49% and 74%, respectively. And no activity against other 55 recombinant receptors (GPCR, transporters, ion channels). GSK-LSD1 2HCl can be used as a chemical probe and a part of the SGC epigenetics

靶点：

HistoneDemethylase

体外研究：

GSK-LSD1 induces gene expression changes in cancer cell lines with average EC50 of < 5 nM and inhibits cancer cell line growth with average EC50 of < 5 nM. [1]

参考文献：

1. Structural Genomics Consortium.http://www. thesgc.org/chemical-probes/LSD1.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.457 ml	17.287 ml	34.573 ml
5 mM	0.691 ml	3.457 ml	6.915 ml
10 mM	0.346 ml	1.729 ml	3.457 ml
50 mM	0.069 ml	0.346 ml	0.691 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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