货号	规格	价格	上海	北京	珠海	重庆	武汉
S89236-5mg买3赠1	96.00%	￥530.00 S89236-5mg ￥530.00 现货（买3赠1）	5 5	-	-	-	-
S89236-10mg买3赠1	96.00%	￥820.00 S89236-10mg ￥820.00 现货（买3赠1）	5 5	-	-	-	-
S89236-25mg买3赠1	96.00%	￥1010.00 S89236-25mg ￥1010.00 现货（买3赠1）	5 5	-	-	-	-
S89236-100mg	≥96%	￥3800.00 S89236-100mg ￥3800.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

WM-3835 is a potent and high-specific HBO1 (KAT7 or MYST2) inhibitor and binds directly to the acetyl-CoA binding site of HBO1 33. WM-3835 activates apoptosis while inhibits osteosarcoma (OS) cell proliferation, migration and invasion. WM-3835 has antitumor activity and potently inhibits pOS-1 xenograft growth in mice

靶点：

HBO1;Apoptosis; HistoneMethyltransferase; HistoneAcetyltransferase

体外研究：

WM-3835 (1-25 uM; 24-96 hours) inhibits pOS-1 cell viability in a concentration-dependent manner. WM-3835 (5 uM; 72 h) activates cell apoptosis and significantly increases TUNEL-positive nuclei in pOS-1 cells. WM-3835 (5 μM; 24 hours) downregulates MYLK-HOXA9 mRNA expression in pOS-1 cells. WM-3835 (1-25 uM) suppresses H4K12ac-H3K14ac in a dose-dependent manner. WM-3835 does not alter the expressions of HBO1 protein and total H3, H4 histones. WM-3835 (5 μM) fails to induce apoptosis and reduction of viability in HBO1-KO pOS-1 cells, koHBO1-1 and koHBO1-2, HBO1-low human osteoblasts Cell Viability Assay Cell Line: Primary human OS (pOS-1) cells Concentration: 1, 5, 10, 25 uM Incubation Time: 24, 48, 72, 96 hours Result: Inhibited pOS-1 cell viability in a concentration-dependent manner.Exerted a significant anti-survival activity at least 48 h, displaying a time-dependent manner. Apoptosis Analysis Cell Line: pOS-1 cells Concentration: 5 uM Incubation Time: 72 hours Result: Activated cell apoptosis and significantly increases TUNEL-positive nuclei. RT-PCR Cell Line: pOS-1 cells Concentration: 5 uM Incubation Time: 24 hours Result: Downregulated MYLK-HOXA9 mRNA expression.

体内研究：

WM-3835 (10 mg/kg/day; ip; for21 days) potently inhibits pOS-1 xenograft growth in SCID mice. Animal Model: SCID mice (18-19 g, female) with pOS1 cells Dosage: 10 mg/kg Administration: IP; daily; for 21 days Result: Potently inhibited pOS-1 xenograft growth.

参考文献：

1. Yan-Yang Gao, et al. The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma. Theranostics. 2021 Mar 4;11(10):4599-4615.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.497 ml	12.487 ml	24.974 ml
5 mM	0.499 ml	2.497 ml	4.995 ml
10 mM	0.25 ml	1.249 ml	2.497 ml
50 mM	0.05 ml	0.25 ml	0.499 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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浓度

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分子摩尔量

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WM 3835

WM 3835; WM3835; WM-3835;

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)