货号	规格	价格	上海	北京	珠海	重庆	武汉
S89237-5mg	99.70%	￥204.00 S89237-5mg ￥204.00 现货	4 4	-	-	-	-
S89237-10mg	99.70%	￥350.00 S89237-10mg ￥350.00 现货	7 7	-	-	-	-
S89237-25mg	99.70%	￥520.00 S89237-25mg ￥520.00 现货	5 5	-	-	-	-
S89237-100mg	≥98%	￥1330.00 S89237-100mg ￥1330.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

MYLS22 是一种选择性的 optic atrophy 1 (OPA1) 抑制剂，具有抗血管生成和抗癌活性

体外研究：

Opa1 inhibitor MYLS22 can result in higher maximal and residual cytoplasmic calcium levels, and alter T cell receptor (TCR) signaling in thymocytes with higher susceptibility to apoptosis

体内研究：

MYLS22, a small molecule first-in-kind Opa1-specific inhibitor, can affect angiogenesis, tumor growth and metastasis by impinging on NF-κB activity and on angiogenic gene expression.

细胞实验：

Cell lines: Jurkat cells Concentrations: 50 μM Incubation Time: 2 h Method: Jurkat cells are cultured in 1640 media supplemented with 10% FCS, 4 mM L-glutamine, 1 penicillin/streptomycin, and 55 μM β-mercaptoethanol under 5% CO2, atmospheric oxygen, at 37 °C in a humidified incubator. For MYLS22 treatment, cells are ished and resuspended in RPMI supplemented with 2% FCS and 50 μM MYLS22 for 2 h before the experiment is started.The treated cells are used for Calcium measurements, Flow cytometry, Electron microscopy, and Western blotting.

动物实验：

Animal Models: C57BL6/J mice(Opa1+/ΔEC, Opa1iΔEC, Opa1+/iΔEC, Opa1+/ΔEC, Mfn1iΔEC) Dosages: 10 mg/kg Administration: i.p.

参考文献：

1. Stéphanie Herkenne, et al. Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1. Cell Metab. 2020 May 5;31(5):987-1003.e8. 2. Corrado M, et al. Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism. Cell Death Differ. 2021 Jul; 28(7): 2194–2206.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.255 ml	11.273 ml	22.547 ml
5 mM	0.451 ml	2.255 ml	4.509 ml
10 mM	0.225 ml	1.127 ml	2.255 ml
50 mM	0.045 ml	0.225 ml	0.451 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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