货号	规格	价格	上海	北京	珠海	重庆	武汉
S89240-5mg买3赠1	98.50%	￥400.00 S89240-5mg ￥400.00 现货（买3赠1）	5 5	-	-	-	-
S89240-10mg促销	98.50%	￥550.00 ￥440.00 S89240-10mg ￥440.00 现货	7 7	-	-	-	-
S89240-25mg促销	98.50%	￥1110.00 ￥888.00 S89240-25mg ￥888.00 现货	5 5	-	-	-	-
S89240-100mg促销	≥98%	￥3220.00 ￥2570.00 S89240-100mg ￥2570.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Dac51 是一种有效的 FTO 抑制剂，抑制 FTO 去甲基化的 IC50 为 0.4 μM

体外研究：

Dac51 can serve as a potent FTO inhibitor to dampen the glycolytic capacity of tumor cells by inhibiting FTO-mediated demethylation on transcripts including Jun and Cebpb.

体内研究：

Dac51, a FTO inhibitor, delivers strong T cell-mediated antitumor effects and prevents tumor recurrence via increasesing CD8+ T cell inﬁltration in tumors, in multiple vivo cancer models

细胞实验：

Cell lines: B16-OVA cells, LLC cell line, LLC-zsGreen-OTIp cells, MC38 cell line Concentrations: 1 mM, 5 mM Incubation Time: 48 h Method: Cells are cultured in Dulbecco s modified Eagles medium supplemented with 10% heat-inactivated fetal bovine serum, 2 mM L-glutamine, 10 mM HEPES, and 1% non-essential amino acids at 37 ℃ 5% CO2. Cells are cultured with Dac51 (1 mM, 5mM) for 48 hr.Then cell growth is monitored by Trypan Blue staining. Apoptosis is analyzed through ﬂow cytometry. Cell total RNA is extracted for m6A dot blot assay.

动物实验：

Animal Models: C57BL/6 mice inoculated with Fto-Kd or B16-OVA tumor cells, Rag2/ mice inoculated with B16-OVA cells Dosages: 2 mg/kg Administration: i.p.

参考文献：

1. Yi Liu, et al. Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance. Cell Metab. 2021 Jun 1;33(6):1221-1233.e11.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.556 ml	12.78 ml	25.559 ml
5 mM	0.511 ml	2.556 ml	5.112 ml
10 mM	0.256 ml	1.278 ml	2.556 ml
50 mM	0.051 ml	0.256 ml	0.511 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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UUN44923

Benzamide, 2-[[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino]-N-hydroxy-

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)