货号	规格	价格	上海	北京	珠海	重庆	武汉
S89247-5mg买3赠1	98.50%	￥184.00 S89247-5mg ￥184.00 现货（买3赠1）	5 5	-	-	-	-
S89247-10mg买3赠1	98.50%	￥320.00 S89247-10mg ￥320.00 现货（买3赠1）	5 5	-	-	-	-
S89247-25mg促销	98.50%	￥526.00 ￥420.00 S89247-25mg ￥420.00 现货	5 5	-	-	-	-
S89247-100mg促销	98.50%	￥1190.00 ￥952.00 S89247-100mg ￥952.00 现货	3 3	-	-	-	-

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产品描述：

A2793 is an efficient dual TWIK-related acid-sensitive K+ channel (TASK)-1/TRESK inhibitor, with an IC50 of 6.8 μM for mTRESK. A2764 is more selective for TRESK, and it only moderately influences TREK-1 and TALK-1

靶点：

IC50: 6.8 μM (mTRESK);PotassiumChannel

体外研究：

A2793 (100 µM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5). A2793 inhibits TASK-1 (100 µM, 53.4±13,5%, n=5), while A2764 is more selective for TRESK, it only moderately influences TREK-1 and TALK-1. A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1

参考文献：

1. Miklós Lengyel, et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K 2P 18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0 ml	0 ml	0 ml
5 mM	0 ml	0 ml	0 ml
10 mM	0 ml	0 ml	0 ml
50 mM	0 ml	0 ml	0 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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