| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89256-5mg买3赠1 |
99.00% | ￥230.00 |
6 | - | - | - | - |
|
S89256-10mg促销 |
99.00% | ￥360.00 ￥288.00 |
6 | - | - | - | - |
|
S89256-25mg促销 |
99.00% | ￥510.00 ￥408.00 |
3 | - | - | - | - |
|
S89256-100mg促销 |
≥98% | ￥1430.00 ￥1280.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM). KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Caspase 3:10 μM (IC50);Thioredoxin:10 μM (IC50);Apoptosis; Others; Caspase | ||||||||||||||||||||
| 体外研究： | KEA1-97 (100 μM; 231MFP cells) impaires thioredoxin pulldown of caspase 3. KEA1-97 (10 μM; 48 hours; 231MFP cells) impaires 231MFP serum-free cell proliferation. KEA1-97 (10 μM; 0~12 hours; 231MFP cells) activates caspase 3/7 and induces apoptotic cell death. KEA1-97 (231MFP cells) resistants to survival and proliferation impairments. Western Blot Analysis Cell Line: 231MFP cells Concentration: 100 μM Incubation Time: Result: Impaired thioredoxin pulldown of caspase 3. Cell Proliferation Assay Cell Line: 231MFP cells Concentration: 10 μM Incubation Time: 48 h Result: Impaired 231MFP serum-free cell proliferation. Apoptosis Analysis Cell Line: 231MFP cells Concentration: 10 μM Incubation Time: 0~12 h Result: Activated caspase 3/7 and induced apoptotic cell death. | ||||||||||||||||||||
| 体内研究： | KEA1-97 (5 mg/kg; i.p.; 50 days) attenuates tumor xenograft growth. Animal Model: Immune-deficient SCID mice Dosage: 5 mg/kg Administration: I.p.; 50 days Result: Attenuated tumor xenograft growth. | ||||||||||||||||||||
| 参考文献： | 1. Anderson KE, To M, Olzmann JA, Nomura DK. Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity. ACS Chem Biol. 2017 Oct 20;12(10):2522-2528. doi: 10.1021/acschembio.7b00711. Epub 2017 Sep 13. PubMed PMID: 28892616. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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