货号	规格	价格	上海	北京	珠海	重庆	武汉
S89267-5mg买3赠1	99.20%	￥430.00 S89267-5mg ￥430.00 现货（买3赠1）	5 5	-	-	-	-
S89267-25mg促销	99.20%	￥820.00 ￥656.00 S89267-25mg ￥656.00 现货	1 1	-	-	-	-
S89267-10mg买3赠1	99.20%	￥680.00 S89267-10mg ￥680.00 现货（买3赠1）	6 6	-	-	-	-
S89267-100mg促销	≥98%	￥2350.00 ￥2110.00 S89267-100mg ￥2110.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer

靶点：

Hsp90-Cdc37 PPI;HSP

体外研究：

DDO-5936 is a Hsp90-Cdc37 PPI inhibitor with potency and specificity through binding to a critical site on Hsp90 involving Glu47

体内研究：

DDO-5936 (0~80 mg/kg; p.o.) shows effect at the high dose group. DDO-5936 is well tolerated for the absence of serious weight loss. DDO-5936 high dose groups show that tumor cells in the xenografts decreased significantly. DDO-5936 shows limited oral efficiency. Animal Model: Mice Dosage: 0~80 mg/kg Administration: P.o. Result: Showed a moderate effect at the high dose group.

参考文献：

1. Wang L, et al. Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer. J Med Chem. 2020;63(3):1

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.018 ml	10.089 ml	20.178 ml
5 mM	0.404 ml	2.018 ml	4.036 ml
10 mM	0.202 ml	1.009 ml	2.018 ml
50 mM	0.04 ml	0.202 ml	0.404 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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