货号	规格	价格	上海	北京	珠海	重庆	武汉
S89275-5mg买3赠1	99.00%	￥250.00 S89275-5mg ￥250.00 现货（买3赠1）	6 6	-	-	-	-
S89275-10mg买3赠1	99.00%	￥420.00 S89275-10mg ￥420.00 现货（买3赠1）	5 5	-	-	-	-
S89275-25mg	99.00%	￥790.00 S89275-25mg ￥790.00 现货	5 5	-	-	-	-
S89275-100mg	≥98%	￥2280.00 S89275-100mg ￥2280.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Endovion (NS3728) is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor

靶点：

Chloride channel, VRAC/VSOAC.ANO1;Chloridechannel

体外研究：

Endovion (NS3728, 10-100 μM) reduces TNFα-induced apoptosis and increases p53-protein level as well as downstream signaling, e.g., expression of p21Waf1/Cip1, Bax, Noxa, MDM2, and activation of Caspase-9/-3 in Cisplatin-sensitive cells. Endovion (NS3728, 10 μM) inhibits cell proliferation in Capan-1, AsPC-1 and BxPC-3 cell lines. Western Blot Analysis Cell Line: Wild-type, resistant, and transiently transfected A2780 cells. Concentration: 10-100 μM. Incubation Time: 18 or 4.5 h. Result: Reduced the maximal taurine rate constant more than 90% compared with the untreated control cells.Resulted in an increased LRRC8A protein expression.Significantly reduceed p53 and p21Waf1/Cip1 protein level in A2780WT cells. Cell Proliferation Assay Cell Line: Capan-1, AsPC-1, BxPC-3 and H6c7 cell lines. Concentration: 10 μM. Incubation Time: 24 h. Result: Resulted in the most pronounced inhibition in all cell lines with 77 ± 26 % in Capan-1, 67 ± 9 % in AsPC-1, and 54 ± 8 % in BxPC-3 cells at +67 mV.

参考文献：

1. Sørensen BH, et al. Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against CDDP-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C857-73. 2. Sauter DR, et al. ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC). Pflugers Arch. 2015 Jul;467(7):1495-1508.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.019 ml	10.097 ml	20.195 ml
5 mM	0.404 ml	2.019 ml	4.039 ml
10 mM	0.202 ml	1.01 ml	2.019 ml
50 mM	0.04 ml	0.202 ml	0.404 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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