PS210

99.90%

PS210

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品牌：源叶(MedMol)

产品编号：S89279 一键复制产品信息

CAS号：1221962-86-2

分子式：C₁₉H₁₅F₃O₅

分子量：380.3

别名：PS210; PS-210; PS 210;2-(3-Oxo-1-phenyl-3-(4-(trifluoromethyl)phenyl)propyl)malonic acid

货号	规格	价格	上海	北京	珠海	重庆	武汉
S89279-5mg	99.90%	￥480.00 S89279-5mg ￥480.00 现货	5 5	-	-	-	-
S89279-10mg	99.90%	￥800.00 S89279-10mg ￥800.00 现货	6 6	-	-	-	-
S89279-25mg	99.90%	￥1600.00 S89279-25mg ￥1600.00 现货	5 5	-	-	-	-
S89279-100mg	≥98%	￥4800.00 S89279-100mg ￥4800.00 2-3天	0 货期：2-3天	-	-	-	-

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产品介绍参考文献(1篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

PS210 is a potent and selective PDK1 activator with a Kd of 3 μM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K

靶点：

Kd: 3 μM (PDK1);PDK

体外研究：

When PS210 induces a stabilization of PDK1 to the temperature gradien, PS210 stabilized the residue Arg131, located opposite to the helix a-B at the other extreme of the helix a-C. Thus, the residues forming part of the phosphate-binding site appear to be a fixed point that allows for the relative movement of the helices in the process of PDK1 activation.

参考文献：

1. Busschots K, et al. Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site. Chem Biol. 2012 Sep 21;19(9):1152-63. 2. Rettenmaier TJ, et al. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.63 ml	13.148 ml	26.295 ml
5 mM	0.526 ml	2.63 ml	5.259 ml
10 mM	0.263 ml	1.315 ml	2.63 ml
50 mM	0.053 ml	0.263 ml	0.526 ml