| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89294-5mg买3赠1 |
99.80% | ￥360.00 |
6 | - | - | - | - |
|
S89294-10mg买3赠1 |
99.80% | ￥640.00 |
6 | - | - | - | - |
|
S89294-25mg促销 |
99.80% | ￥1160.00 ￥928.00 |
5 | - | - | - | - |
|
S89294-100mg促销 |
≥98% | ￥2870.00 ￥2290.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | SR18662 是一种基于ML264的优化化合物，可抑制 Krüppel-like factor 5 (KLF5) 对应的IC50值为4.4 nM。SR18662 可降低多种结直肠癌细胞系的生存能力并诱导凋亡 | ||||||||||||||||||||
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| 靶点： | KLF5(Cell-free assay):4.4 nM | ||||||||||||||||||||
| 体内研究： | A significant dose-dependent inhibition of xenograft growth in mice is observed following SR18662 treatment that exceeds the effect of ML264 at equivalent doses. SR18662 is potential for colorectal cancer therapy. | ||||||||||||||||||||
| 细胞实验： | Cell lines: DLD-1, HCT116, HT29 and SW620 colorectal cancer cell lines Concentrations: 0.001 μM-20 μM Incubation Time: 24 h Method: KLF5 promoter activity assay: DLD-1/pGL4.18hKLF5p cells are seeded in 96 well plate format and treated with DMSO or with SR18662 dissolved in DMSO in the range of 0.001 to 20 μM final concentration for 24 h and the human KLF5 promoter activity is determined with the ONE-Glo luciferase assay system using a SpectramMax M3 plate reader. | ||||||||||||||||||||
| 动物实验： | Animal Models: 7-week-old male NuJ/Foxn1nu mice with DLD-1 human colorectal cells injected Dosages: 5 mg/kg, 10 mg/kg, 25 mg/kg Administration: IP | ||||||||||||||||||||
| 参考文献： | 1. Julie Kim, et al. Mol Cancer Ther. 2019 Nov;18(11):1973-1984. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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