货号	规格	价格	上海	北京	珠海	重庆	武汉
S89295-5mg	≥98%	￥1490.00 S89295-5mg ￥1490.00 3-5天	0 货期：3-5天	-	-	-	-
S89295-10mg	≥98%	￥2490.00 S89295-10mg ￥2490.00 3-5天	0 货期：3-5天	-	-	-	-
S89295-25mg	≥98%	￥4490.00 S89295-25mg ￥4490.00 3-5天	0 货期：3-5天	-	-	-	-
S89295-100mg	≥98%	￥10300.00 S89295-100mg ￥10300.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

LOX-IN-3 is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 can be used for fibrosis, cancer and angiogenesis research

靶点：

IC50: <1 μM (human LOXL2), <10 μM (bovine LOX)

体外研究：

LOX-IN-3 (Compound 33) inhibits the bovine LOX and human LOXL2 activities with IC50 values of <10 μM and <1 μM, respectively. LOX-IN-3 is less active against SSAO/VAP-1 and MAO-B activities.

体内研究：

LOX-IN-3 dihydrochloride monohydrate (Compound 33) (30 mg/kg; orally; once) inhibits lysyl oxidase activity in rats. LOX-IN-3 dihydrochloride monohydrate (10 mg/kg; orally; daily for 14 days) reduces kidney fibrosis in unilateral ureteric obstruction (UUO) mice model. LOX-IN-3 dihydrochloride monohydrate (15 mg/kg; orally; daily for 21 days) reduces lung fibrosis in mice. Animal Model: Male Wistar rats Dosage: 30 mg/kg Administration: Oral administration, single dose Result: Completely abolished lysyl oxidase activity. Plasma concentrations of tested compound are far below the IC50 after 8 hours, the half-life of recovery is between 2-3 days (ear) and 24 hours (aorta).Animal Model: Unilateral ureteric obstruction (UUO) model of acute kidney fibrosis in mice[1]Dosage: 10 mg/kgAdministration: Oral gavage, daily for 14 daysResult: Increased kidney weight and thickness and reduced the area of fibrosis.Animal Model: C57Bl/6 mice, Bleomycin-induced lung fibrosis modelDosage: 15 mg/kgAdministration: Oral gavage, daily for 21 daysResult: Significantly reduced the Ashcroft score and the lung weight.

参考文献：

1. Alison Dorothy Findlay, et al. Haloallylamine sulfone derivative inhibitors of lysyl oxidases and uses thereof. WO2020024017A1.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.567 ml	17.837 ml	35.674 ml
5 mM	0.713 ml	3.567 ml	7.135 ml
10 mM	0.357 ml	1.784 ml	3.567 ml
50 mM	0.071 ml	0.357 ml	0.713 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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