货号	规格	价格	上海	北京	珠海	重庆	武汉
S89296-5mg促销	98.09%	￥1110.00 ￥888.00 S89296-5mg ￥888.00 现货	5 5	-	-	-	-
S89296-10mg促销	98.09%	￥1800.00 ￥1440.00 S89296-10mg ￥1440.00 现货	7 7	-	-	-	-
S89296-25mg促销	98.09%	￥3210.00 ￥2560.00 S89296-25mg ￥2560.00 现货	4 4	-	-	-	-
S89296-100mg促销	≥98%	￥6530.00 ￥5220.00 S89296-100mg ￥5220.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Bemnifosbuvir hemisulfate (AT-527), a hemisulfate salt of AT-511, a guanosine nucleotide proagent, is a potent and orally active HCV viral replication inhibitor. Bemnifosbuvir hemisulfate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM). Bemnifosbuvir hemisulfate has pangenotypic antiviral activity

靶点：

EC50: 5-28 nM (HCV); EC90: 0.47 μM (SARS-CoV-2);HCVProtease; SARS-CoV

体外研究：

Bemnifosbuvir hemisulfate has pan-genotypic antiviral activities that inhibits HCV genotype 1a (HCV GT1a), HCV GT1b, HCV GT2a, HCV GT3a, HCV GT4a, and HCV GT5a replication with EC50 values of 12.8 nM, 12.5 nM, 9.2 nM, 10.3 nM, 14.7 nM, and 28.5 nM, respectively.
In normal human airway epithelial cells, the concentration of Bemnifosbuvir hemisulfate required to inhibit replication of SARS-CoV-2 by EC90 is 0.47 μM, very similar to its EC90 against HCoV-229E, HCoV-OC43 and SARS-CoV in Huh-7 cells.

体内研究：

When given orally to rats (500 mg/kg) and monkeys (30 mg/kg, 100 mg/kg or 300 mg/kg), Bemnifosbuvir hemisulfate preferentially delivers high levels of AT-9010 in the liver in vivo.

参考文献：

1. Steven S Good, et al. Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus. PLoS One. 2020 Jan 8;15(1):e0227104. 2. Steven S Good, et al. AT-527, a double prodrug of a guanosine nucleotide analog, is a potent inhibitor of SARS-CoV-2 in vitro and a promising oral antiviral for treatment of COVID-19. Antimicrob Agents Chemother. 2021 Feb 8;AAC.02479-20. 3. Elina Berliba, et al. Safety, pharmacokinetics and antiviral activity of AT-527, a novel purine nucleotide prodrug, in HCV-infected subjects with and without cirrhosis. Antimicrob Agents Chemother. 2019 Sep 30;63(12):e01201-19.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.586 ml	7.929 ml	15.858 ml
5 mM	0.317 ml	1.586 ml	3.172 ml
10 mM	0.159 ml	0.793 ml	1.586 ml
50 mM	0.032 ml	0.159 ml	0.317 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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