货号	规格	价格	上海	北京	珠海	重庆	武汉
S89309-5mg买3赠1	99.90%	￥410.00 S89309-5mg ￥410.00 现货（买3赠1）	5 5	-	-	-	-
S89309-10mg买3赠1	99.90%	￥670.00 S89309-10mg ￥670.00 现货（买3赠1）	5 5	-	-	-	-
S89309-25mg促销	99.90%	￥1250.00 ￥1000.00 S89309-25mg ￥1000.00 现货	5 5	-	-	-	-
S89309-100mg促销	99.90%	￥3900.00 ￥3120.00 S89309-100mg ￥3120.00 现货	3 3	-	-	-	-

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产品描述：

CB1 antagonist 2 is caimabinoid 1 (CB1) antagonist extracted from patent WO2016184310A1, compound 3, inhibits CB1 in vivo with an IC50 of 25.5 nM

靶点：

Cannabinoid Receptor;CannabinoidReceptor

体外研究：

AM4113 was able to bind with high affinity to CB1 receptors, exhibiting 100-fold selectivity for CB1 against CB2 receptors. The Ki value for CB1 was 0.897 ± 0.44 nM, while the Ki value for hCB2 was 92 ± 6.9 nM .

体内研究：

In rats, treatment with AM4113 (2.0 and 4.0 mg/kg) attenuated the AM411-induced locomotor suppression and analgesia. In addition, 4.0 mg/kg AM4113 alone significantly suppressed locomotor activity when compared with vehicle. AM4113 dose-dependently decreased lever pressing on an FR1 schedule. AM4113 produced conditioned taste avoidance and suppression of ingestive (hedonic) taste reactivity scores in a dose-dependent manner [1]. AM4113 didn’t induce signs of nausea .

参考文献：

1. Song Li, et al. 4-methyl-diaryl -1H- pyrazole derivatives and their use as medicamentsFIELD.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.627 ml	13.135 ml	26.271 ml
5 mM	0.525 ml	2.627 ml	5.254 ml
10 mM	0.263 ml	1.314 ml	2.627 ml
50 mM	0.053 ml	0.263 ml	0.525 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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体积

分子摩尔量

计算重置

CB1 ANTAGONIST 2