| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89310-5mg促销 |
99.20% | ￥140.00 ￥112.00 |
6 | - | - | - | - |
|
S89310-10mg促销 |
99.20% | ￥260.00 ￥208.00 |
9 | - | - | - | - |
|
S89310-25mg促销 |
99.20% | ￥440.00 ￥352.00 |
6 | - | - | - | - |
|
S89310-100mg |
≥98% | ￥1110.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | SGC-AAK1-1 is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC50 of 270 nM and a Ki of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1 | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 270 nM (AAK1). Ki: 9 nM (AAK1);AAK1(AP2associatedkinase1) | ||||||||||||||||||||
| 体外研究： | SGC-AAK1-1 (1.25 μM) significantly reduces phosphorylation of AP2M1 (T156) and activates WNT-driven BAR activity compared in a dose-dependent manner in HT1080 cells. SGC-AAK1-1 blocks AAK1 kinase activity, resulting in increased β-catenin protein stability and β-catenin-dependent transcription. |
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| 参考文献： | 1. Agajanian MJ, Walker MP, Axtman AD, et al. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Rep. 2019;26(1):79-93.e8. doi:10.1016/j.celrep.2018.12.023 | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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