货号	规格	价格	上海	北京	珠海	重庆	武汉
S89352-5mg促销	99.40%	￥1530.00 ￥1220.00 S89352-5mg ￥1220.00 现货	6 6	-	-	-	-
S89352-10mg促销	99.40%	￥2550.00 ￥2040.00 S89352-10mg ￥2040.00 现货	6 6	-	-	-	-
S89352-25mg促销	99.40%	￥5100.00 ￥4080.00 S89352-25mg ￥4080.00 现货	5 5	-	-	-	-
S89352-100mg促销	≥98%	￥9500.00 ￥7600.00 S89352-100mg ￥7600.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

OSBPL7-IN-1 is an orally active oxysterol binding protein like 7 (OSBPL7) inhibitor. OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression

靶点：

OSBPL7 ABCA1

体外研究：

OSBPL7-IN-1 (compound G or Cpd G; 1-10 µM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux.

体内研究：

OSBPL7-IN-1 (100 mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria and prevents renal function decline in mouse models of proteinuric kidney disease. Animal Model:Female Balb/c mice induced by Adriamycin (ADR) Dosage:100 mg/kg Administration:Oral gavage; daily; for 28 days Result:Normalized proteinuria, and significantly reduced renal fibrosis and renal functional decline.

参考文献：

1. Matthew B Wright, et al. Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease. Nat Commun. 2021 Aug 2;12(1):4662.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.159 ml	10.793 ml	21.585 ml
5 mM	0.432 ml	2.159 ml	4.317 ml
10 mM	0.216 ml	1.079 ml	2.159 ml
50 mM	0.043 ml	0.216 ml	0.432 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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