货号	规格	价格	上海	北京	珠海	重庆	武汉
S89353-5mg	98%	￥188.00 S89353-5mg ￥188.00 3-5天	0 货期：3-5天	-	-	-	-
S89353-10mg	98%	￥315.00 S89353-10mg ￥315.00 3-5天	0 货期：3-5天	-	-	-	-
S89353-25mg	98%	￥650.00 S89353-25mg ￥650.00 3-5天	0 货期：3-5天	-	-	-	-
S89353-100mg	98%	￥1450.00 S89353-100mg ￥1450.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. The observed parallel rightward shift of concentration-response curves with different antagonist concentrations is consistent with a competitive binding mode. Since R0 46-8443 selectively inhibits ETB receptor mediated responses, it is a valuable tool for clarifying the role of ETB receptors in pathology.

靶点：

ET-B

参考文献：

1: Guimarães CL, Trentin PG, Rae GA. Endothelin ET(B) receptor-mediated mechanisms involved in oleic acid-induced acute lung injury in mice. Clin Sci (Lond). 2002 Aug;103 Suppl 48:340S-344S. PubMed PMID: 12193118.
2: Parent R, Lavallée M. Endothelin-dependent effects limit flow-induced dilation of conductance coronary vessels after blockade of nitric oxide formation in conscious dogs. Cardiovasc Res. 2000 Jan 14;45(2):470-7. PubMed PMID: 10728368.
3: Thorin E, Parent R, Ming Z, Lavallée M. Contribution of endogenous endothelin to large epicardial coronary artery tone in dogs and humans. Am J Physiol. 1999 Aug;277(2 Pt 2):H524-32. PubMed PMID: 10444477.
4: Ming Z, Parent R, Thorin E, Lavallée M. Endothelin-dependent tone limits acetylcholine-induced dilation of resistance coronary vessels after blockade of NO formation in conscious dogs. Hypertension. 1998 Nov;32(5):844-8. PubMed PMID: 9822442.

溶解性：

Soluble in DMSO, not in water

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.64 ml	8.201 ml	16.402 ml
5 mM	0.328 ml	1.64 ml	3.28 ml
10 mM	0.164 ml	0.82 ml	1.64 ml
50 mM	0.033 ml	0.164 ml	0.328 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

RO 46-8443

4-(tert-butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)