| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89366-5mg买3赠1 |
99.40% | ￥510.00 |
7 | - | - | - | - |
|
S89366-10mg买3赠1 |
99.40% | ￥816.00 |
6 | - | - | - | - |
|
S89366-25mg促销 |
99.40% | ￥1360.00 ￥1080.00 |
5 | - | - | - | - |
|
S89366-100mg促销 |
≥98% | ￥4420.00 ￥3530.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function | ||||||||||||||||||||
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| 体外研究： | BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines. BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines. BT18 (5-50 μM; 15 mimutes) appears to phosphorylate RET in concentration of 50 µM both in GFP-transfected and in GFRD1-transfected cells. Western Blot Analysis Cell Line: MG87RET cell lines Concentration: 50 μM Incubation Time: 1, 5, 15, 45, 90 minutes Result: Activated AKT and ERK1/2 in time-dependently. | ||||||||||||||||||||
| 参考文献： | 1. Leo Jakman, Characterization of small-molecule GDNF mimics. 2. Ivanova L, et al. Molecular Dynamics Simulations of the Interactions between Glial Cell Line-DerivedNeurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands. ACS Omega. 2018 Sep 30;3(9):11407-11414. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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