货号	规格	价格	上海	北京	珠海	重庆	武汉
S89383-5mg买3赠1	≥98%	￥470.00 S89383-5mg ￥470.00 现货（买3赠1）	100 >10	-	-	-	-
S89383-10mg买3赠1	≥98%	￥760.00 S89383-10mg ￥760.00 现货（买3赠1）	50 >10	-	-	-	-
S89383-25mg买3赠1	≥98%	￥1530.00 S89383-25mg ￥1530.00 现货（买3赠1）	20 >10	-	-	-	-
S89383-100mg买3赠1	≥98%	￥3510.00 S89383-100mg ￥3510.00 现货（买3赠1）	5 5	-	-	-	-

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产品描述：

BZAD01 is a selective NMDA NR1A/2B receptor antagonist.

靶点：

NMDAR

体内研究：

Parkinsonism was induced by microinjection of the toxin, 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle (MFB) of 40 Sprague-Dawley rats. Parkinsonism and the efficacy of drugs were assessed using a battery of behavioural tests including balance beam, apomorphine-induced rotation, body axis bias or 'curling', head position bias and disengage sensorimotor latency test. The main effects were that BZAD01 co-administration prevented chronic levodopa-induced potentiation of apomorphine rotation. However levodopa-treated rats were slower than either controls or BZAD-01-treated rats in the locomotor test

参考文献：

1. Beinat C, et al. Structure-activity relationships of N-substituted 4-(trifluoromethoxy)benzamidines with affinity for GluN2B-containing NMDA receptors. Bioorg Med Chem Lett. 2014 Feb 1;24(3):828-30. 2. Warraich ST, et al. Evaluation of behavioural effects of a selective NMDA NR1A/2B receptor antagonist in the unilateral 6-OHDA lesion rat model. Brain Res Bull. 2009 Feb 16;78(2-3):85-90. 3. Leaver KR, et al. Neuroprotective effects of a selective N-methyl-D-aspartate NR2B receptor antagonist in the 6-hydroxydopamine rat model of Parkinson's disease. Clin Exp Pharmacol Physiol. 2008 Nov;35(11):1388-94.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.76 ml	13.802 ml	27.604 ml
5 mM	0.552 ml	2.76 ml	5.521 ml
10 mM	0.276 ml	1.38 ml	2.76 ml
50 mM	0.055 ml	0.276 ml	0.552 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

BZAD01

BZAD01; BZAD-01; BZAD 01;

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)