货号	规格	价格	上海	北京	珠海	重庆	武汉
S89399-1mg促销	≥98%	￥648.00 ￥582.00 S89399-1mg ￥582.00 现货	10 10	-	-	-	-
S89399-5mg促销	≥98%	￥1570.00 ￥1410.00 S89399-5mg ￥1410.00 现货	10 10	-	-	-	-
S89399-10mg促销	≥98%	￥2500.00 ￥2250.00 S89399-10mg ￥2250.00 现货	9 9	-	-	-	-
S89399-25mg促销	≥98%	￥4630.00 ￥4170.00 S89399-25mg ￥4170.00 现货	8 8	-	-	-	-
S89399-50mg促销	≥98%	￥7230.00 ￥6500.00 S89399-50mg ￥6500.00 现货	3 3	-	-	-	-

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产品描述：

IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression

靶点：

AMPK

体外研究：

IMM-H007 (H007) significantly inhibits monocyte adhesion to endothelial cells and its transendothelial migration. Mechanistically, H007 markedly represses TNFα-induced IκBα degradation and NF-κB nuclear translocation, therefore leading to NF-κB-mediated inflammatory suppression. Moreover, another inflammatory signaling JNK/c-Jun, which is always co-activated with NF-κB in response to pro-inflammatory stimuli, is also found to be restrained by H007 through reducing its phosphorylation status. H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling.

体内研究：

IMM-H007 inhibits fatty acid import into hepatocytes and liver lipogenesis, and concomitantly stimulates fatty acid oxidation, autophagy, and export of hepatic lipids.
IMM-H007 (200 mg/kg, Orally, once per day for 10 days) inhibits ISO-induced cardiac fibrosis and diastolic dysfunction independently of AMPKα2 expression, reduces ISO-induced Smad2/3 phosphorylation downstream of TGFβ1 and cardiac fibrosis via an AMPKα2-independent pathway, but the inhibition of TGFβ1 expression is AMPKα2-dependent.

参考文献：

1. Jy C , MD Hong, Hyl F , et al. IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling[J]. Toxicology and Applied Pharmacology, 2019, 381:114732-.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.06 ml	10.3 ml	20.599 ml
5 mM	0.412 ml	2.06 ml	4.12 ml
10 mM	0.206 ml	1.03 ml	2.06 ml
50 mM	0.041 ml	0.206 ml	0.412 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

IMM-H007

N-(3-Hydroxyphenyl)adenosine 2',3',5'-triacetate

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)