货号	规格	价格	上海	北京	珠海	重庆	武汉
S89412-5mg	99.60%	￥950.00 S89412-5mg ￥950.00 现货	4 4	-	-	-	-
S89412-10mg	99.60%	￥1540.00 S89412-10mg ￥1540.00 现货	4 4	-	-	-	-
S89412-25mg	99.60%	￥2590.00 S89412-25mg ￥2590.00 现货	4 4	-	-	-	-
S89412-100mg	≥98%	￥5000.00 S89412-100mg ￥5000.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead

靶点：

Proteasome; Apoptosis; Reactive Oxygen Species

体内研究：

RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice. Animal Model: RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice. Dosage: 10 mg/kg. Administration: IP for a 5 days on, 2 days off cycle for two weeks. Result: Reduced ovarian tumor burden in mice. Animal Model: Female Balb/c mice. Dosage: 5, 10, 20, 40, 60, 100 mg/kg (Pharmacological Analysis). Administration: IP single dose. Result: The dose of 40 mg/kg on alternate days for two weeks produced no observable toxicities or weight loss.

参考文献：

1. Ravi K Anchoori, et al. Structure-function Analyses of Candidate Small Molecule RPN13 Inhibitors With Antitumor Properties. PLoS One. 2020 Jan 15;15(1):e0227727.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.698 ml	8.489 ml	16.978 ml
5 mM	0.34 ml	1.698 ml	3.396 ml
10 mM	0.17 ml	0.849 ml	1.698 ml
50 mM	0.034 ml	0.17 ml	0.34 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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