| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89439-5mg |
≥98% | ￥1070.00 |
货期：3-5天 | - | - | - | - |
|
S89439-10mg |
≥98% | ￥1730.00 |
货期：3-5天 | - | - | - | - |
|
S89439-25mg |
≥98% | ￥3400.00 |
货期：3-5天 | - | - | - | - |
|
S89439-100mg |
≥98% | ￥6860.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | DC-S239 is a selective histone methyltransferase SET7 inhibitor with an IC50 value of 4.59 μM. DC-S239 also displays selectivity for DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a. DC-S239 has anticancer activity | ||||||||||||||||||||
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| 靶点： | IC50: 4.59 μM (SET7);HistoneMethyltransferase | ||||||||||||||||||||
| 体外研究： | DC-S239 inhibits DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a by less than 45%, while it inhibits SET7 by 90% at concentrations of 100 μM. DC-S239 (0-100 μM, 120 h) can inhibit the proliferation of MCF7, HL60 and MV4-11 cells in a dose-dependent manner but no significant effect on the activity of HCT116 and DHL4 cells. Cell Viability Assay Cell Line: MCF7, HL60, DHL4, MV4-11 and HCT116 cell lines Concentration: 0-100 μM Incubation Time: 120 h Result: Inhibited MCF7 and HL60 with the IC50 values of 10.93 μM and 16.43 μM, respectively. | ||||||||||||||||||||
| 参考文献： | 1. Fanwang Meng, et al. Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening. J Med Chem. 2015 Oct 22;58(20):8166-81. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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