货号	规格	价格	上海	北京	珠海	重庆	武汉
S89442-5mg买3赠1	95.07%	￥780.00 S89442-5mg ￥780.00 现货（买3赠1）	4 4	-	-	-	-
S89442-10mg买3赠1	95.07%	￥1150.00 S89442-10mg ￥1150.00 现货（买3赠1）	10 10	-	-	-	-
S89442-25mg买3赠1	95.07%	￥1970.00 S89442-25mg ￥1970.00 现货（买3赠1）	3 3	-	-	-	-
S89442-100mg	95.07%	￥5900.00 S89442-100mg ￥5900.00 现货	1 1	-	-	-	-

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产品描述：

ML-SA5 is a potent TRPML1 cation channel agonist that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC50 of 285 nM and is more potent than ML-SA1. ML-SA5 has anticancer activity and can inhibit tumour growth

靶点：

TRP Channel;Autophagy

体外研究：

ML-SA5(1-100 μM, 24 h) has some cell-targeting specificity and induces substantial cell death in M12 and MeWo cells, but fully preserves normal melanocytes. It also causes a loss of mitochondrial membrane potential in M12 cells

体内研究：

ML-SA5 (i.p., 2-5 mg/kg, daily, 2 weeks) reduces muscle necrosis in MDX mice by more than 70% and reduces central nucleated fibers, suggesting that ML-SA5 can improve muscle atrophy in mdx mice in vivo by promoting myosin repair, but has no effect in ML1 knockout mice. Moreover, ML-SA5 reduces skeletal and cardiac muscle damage in mdx mice through ML1 upregulation

参考文献：

1. Wanlu Du, et al. Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma. Cell Rep. 2021 Oct 19;37(3):109848. 2. Lu Yu, et al. Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models. Sci Adv. 2020 Feb 7;6(6):eaaz2736.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.183 ml	10.917 ml	21.835 ml
5 mM	0.437 ml	2.183 ml	4.367 ml
10 mM	0.218 ml	1.092 ml	2.183 ml
50 mM	0.044 ml	0.218 ml	0.437 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

ML-SA5

N1-(3-Chloro-2-(piperidin-1-yl)phenyl)-N4,N4-dimethylbenzene-1,4-disulfonamide

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)