| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89444-5mg买3赠1 |
99.80% | ￥910.00 |
6 | - | - | - | - |
|
S89444-10mg促销 |
99.80% | ￥1310.00 ￥1040.00 |
6 | - | - | - | - |
|
S89444-25mg促销 |
99.80% | ￥2210.00 ￥1760.00 |
5 | - | - | - | - |
|
S89444-100mg促销 |
≥98% | ￥4960.00 ￥3960.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | VPC-70063 is a potent Myc-Max inhibitor with an IC50 value of 8.9 μM for Myc-Max transcriptional activity inhibition. VPC-70063 reduces UBE2C promotor activity and AR-V7 levels, and induces PARP cleavage. VPC-70063 induces apoptosis and blocks Myc-Max interactions with DNA. VPC-70063 can be used for researching anticancer | ||||||||||||||||||||
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| 靶点： | IC50: 8.9 μM (Myc-Max);Apoptosis; PARP; c-Myc | ||||||||||||||||||||
| 体外研究： | VPC-70063 (25 μM; 96 h) shows Myc-Max transcriptional activity inhibition of 106% and Myc-Max/UBE2C downstream pathway inhibition of 94%. VPC-70063 (6.25-25 μM, 48 h) causes apoptosis of LNCaP cells as indicated by cleavage of PARP. VPC-70063 (0-500 μM; 0-600 s) disrupts the interaction of Myc-Max with DNA in a dose dependent manner. Western Blot Analysis Cell Line: LNCaP cells Concentration: 6.25 μM, 12.5 μM and 25 μM Incubation Time: 48 h Result: Induced PARP cleavage. | ||||||||||||||||||||
| 参考文献： | 1. Carabet LA, et al. Computer-aided drug discovery of Myc-Max inhibitors as potential therapeutics for prostate cancer. Eur J Med Chem. 2018 Dec 5;160:108-119. | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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