货号	规格	价格	上海	北京	珠海	重庆	武汉
S89493-5mg买3赠1	98.30%	￥850.00 S89493-5mg ￥850.00 现货（买3赠1）	2 2	-	-	-	-
S89493-10mg买3赠1	≥98%	￥1360.00 S89493-10mg ￥1360.00 3-5天（买3赠1）	0 货期：3-5天	-	-	-	-
S89493-25mg买3赠1	98.30%	￥2720.00 S89493-25mg ￥2720.00 现货（买3赠1）	2 2	-	-	-	-
S89493-100mg	98.30%	￥6780.00 S89493-100mg ￥6780.00 现货	3 3	-	-	-	-

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产品描述：

Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity

靶点：

Mitochondrial Metabolism; ATPase;ATPase; MitochondrialMetabolism

体外研究：

Gboxin, a small molecule that specifically inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic fibroblasts or neonatal astrocytes. Gboxin rapidly and irreversibly compromises oxygen consumption in glioblastoma cells. Gboxin relies on its positive charge to associate with mitochondrial oxidative phosphorylation complexes in a manner that is dependent on the proton gradient of the inner mitochondrial membrane, and it inhibits the activity of F0F1 ATP synthase. Gboxin-resistant cells require a functional mitochondrial permeability transition pore that regulates pH and thus impedes the accumulation of Gboxin in the mitochondrial matrix. Administration of a metabolically stable Gboxin analogue inhibits glioblastoma allografts and patient-derived xenografts. Gboxin toxicity extends to established human cancer cell lines of diverse organ origin, and shows that the increased proton gradient and pH in cancer cell mitochondria is a mode of action that can be targeted in the development of antitumour reagents.

参考文献：

1. Shi Y, et al. Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Nature. 2019 Mar;567(7748):341-346.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.545 ml	12.724 ml	25.447 ml
5 mM	0.509 ml	2.545 ml	5.089 ml
10 mM	0.254 ml	1.272 ml	2.545 ml
50 mM	0.051 ml	0.254 ml	0.509 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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浓度

体积

分子摩尔量

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Gboxin chloride

2-Ethyl-1-(2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-3-methyl-1H-benzo[d]imidazol-3-ium chloride

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)