| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89495-5mg买3赠1 |
98.80% | ￥870.00 |
5 | - | - | - | - |
|
S89495-10mg促销 |
98.80% | ￥1390.00 ￥1110.00 |
8 | - | - | - | - |
|
S89495-25mg促销 |
98.80% | ￥2780.00 ￥2220.00 |
5 | - | - | - | - |
|
S89495-100mg促销 |
≥98% | ￥7890.00 ￥6310.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | TT01001 is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 can be used in studies about the treatment of type II diabetes | ||||||||||||||||||||
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| 靶点： | Mitochondrial Metabolism;MitochondrialMetabolism | ||||||||||||||||||||
| 体内研究： | In type II diabetes model db/db mice, TT01001 improved hyperglycemia, hyperlipidemia, and glucose intolerance, and its efficacy was equivalent to that of pioglitazone, without the pioglitazone-associated weight gain. Mitochondrial complex II + III activity of the skeletal muscle was significantly increased in db/db mice. TT01001 significantly suppressed the elevated activity of the complex II + III | ||||||||||||||||||||
| 参考文献： | 1. Shi G, et al. TT01001 attenuates oxidative stress and neuronal apoptosis by preventing mitoNEET-mediated mitochondrial dysfunction after subarachnoid hemorrhage in rats. Neuroreport. 2020 Aug 5;31(11):845-850. 2. Takahashi T, et al. A novel MitoNEET ligand, TT01001, improves diabetes and ameliorates mitochondrial function in db/db mice. J Pharmacol Exp Ther. 2015 Feb;352(2):338-45. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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