| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89499-5mg |
≥98% | ￥3300.00 |
货期：3-5天 | - | - | - | - |
|
S89499-10mg |
≥98% | ￥4800.00 |
货期：3-5天 | - | - | - | - |
|
S89499-25mg |
≥98% | ￥7500.00 |
货期：3-5天 | - | - | - | - |
|
S89499-100mg |
≥98% | ￥13800.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | AZD1940 is an orally active, high affinity cannabinoid CB1/CB2 receptor agonist with pKi values of 7.93 and 9.06 for human CB1R and CB2R, respectively. AZD1940 shows a robust analgesia action | ||||||||||||||||||||
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| 靶点： | hCB1-R:7.93 (pKi);hCB2-R:9.06 (pKi);CannabinoidReceptor | ||||||||||||||||||||
| 体外研究： | AZD1940 binds with high affinity to human, rat and mouse CB1 and CB2 receptors and displays full agonism at both receptors in all three species | ||||||||||||||||||||
| 体内研究： | When given orally to rats, AZD1940 produces a robust analgesia in different models of inflammatory and neuropathic pain. For AZD1940, low brain uptake at analgesic doses has been demonstrated in both rats and primates. |
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| 参考文献： | 1. Jarkko Kalliomäki, et al. Evaluation of the analgesic efficacy and psychoactive effects of AZD1940, a novel peripherally acting cannabinoid agonist, in human capsaicin-induced pain and hyperalgesia. Clin Exp Pharmacol Physiol. 2013 Mar;40(3):212-8. 2. Magnus Schou, et al. Radiolabeling of the cannabinoid receptor agonist AZD1940 with carbon-11 and PET microdosing in non-human primate. Nucl Med Biol. 2013 Apr;40(3):410-4. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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