• 产品描述： GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids

• 靶点： IC50: 3.92 ± 0.42 nM (LATS2), 4.10 ± 0.79 nM (LATS1)

• 体外研究：
  GA-017 suppresses the cell death of HUVECs and promotes their cell growth.
  GA-017 facilitates SKOV3 cell growth, with an EC50 of 3.51 ± 0.26 μM.
  GA-017 competitively inhibited LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58 ± 0.11 and 0.25 ± 0.03 nM, respectively.

• 参考文献：
  1. Aihara A, Iwawaki T, Abe-Fukasawa N, Otsuka K, Saruhashi K, Mikashima T, Nishino T. Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions. J Biol Chem. 2022 Apr;298(4):101779. doi: 10.1016/j.jbc.2022.101779.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.912 ml	14.561 ml	29.122 ml
  5 mM	0.582 ml	2.912 ml	5.824 ml
  10 mM	0.291 ml	1.456 ml	2.912 ml
  50 mM	0.058 ml	0.291 ml	0.582 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *