货号	规格	价格	上海	北京	珠海	重庆	武汉
S89553-1mg促销	≥98%	￥280.00 ￥252.00 S89553-1mg ￥252.00 现货	6 6	-	-	-	-
S89553-5mg促销	≥98%	￥660.00 ￥594.00 S89553-5mg ￥594.00 现货	4 4	-	-	-	-
S89553-10mg促销	≥98%	￥1070.00 ￥962.00 S89553-10mg ￥962.00 现货	2 2	-	-	-	-
S89553-50mg促销	≥98%	￥3520.00 ￥3160.00 S89553-50mg ￥3160.00 现货	1 1	-	-	-	-

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产品描述：

DRF-1042 is an orally active derivative of Camptothecin. DRF-1042 acts to inhibit DNA topoisomerase I. DRF-1042 shows good anticancer activity against a panel of human cancer cell lines including multi-agent resistance (MDR) phenotype

靶点：

DNA topoisomerase I

体外研究：

DRF-1042 demonstrates superior lactone stability and good in vitro anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype

体内研究：

In clonogenic assay against murine, canine and human bone marrow cells, DRF-1042 treatment shows less mylosupression that supports the possibility of protracted dose schedule in both experimental and clinical studies

参考文献：

1. Chatterjee A, et al. Safety, tolerability, and pharmacokinetics of a capsule formulation of DRF-1042, a novelcamptothecin analog, in refractory cancer patients in a bridging phase I study. J Clin Pharmacol. 2005 Apr;45(4):453-60. 2. Sriram Rajagopal, et al. Preclinical evaluation of the anticancer activity of DRF-1042, a novel camptothecin analog targeting Topoisomerase-I. Published April 2004.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.449 ml	12.243 ml	24.486 ml
5 mM	0.49 ml	2.449 ml	4.897 ml
10 mM	0.245 ml	1.224 ml	2.449 ml
50 mM	0.049 ml	0.245 ml	0.49 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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