| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89559-5mg买3赠1 |
98.00% | ￥370.00 |
5 | - | - | - | - |
|
S89559-10mg买3赠1 |
98.00% | ￥520.00 |
6 | - | - | - | - |
|
S89559-25mg买3赠1 |
98.00% | ￥820.00 |
6 | - | - | - | - |
|
S89559-100mg |
≥98% | ￥1670.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13 nM | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 13±3 nM (human ACMSD) | ||||||||||||||||||||
| 体外研究： | TES-1025 is a low nanomolar human ACMSD inhibitor, which increases NAD+ levels in cellular systems | ||||||||||||||||||||
| 体内研究： | TES-1025 is subjected to in vivo pharmacokinetic studies, following intravenous (IV) and oral (PO) dosings of male CD-1 mice. After the intravenous administration of 0.5 mg/kg, TES-1025 shows low blood clearance, with low volumes of distribution and half-lives (t1/2) of about 5.33 h, although after oral administration at 5 mg/kg, the blood concentration of TES-1025 is quantifiable for up to 8 h. A good systemic exposure is recorded for TES-1025, with a Cmax of 2570 ng/mL reaches at 2 h after dosing. The greater oral exposure of TES-1025 is further confirmed in the liver and kidneys with AUC0-8h of 19 200 h•ng/mL and 36 600 h•ng/mL, respectively | ||||||||||||||||||||
| 参考文献： | 1. Pellicciari R, et al. α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis. J Med Chem. 2018 Feb 8;61(3):745-759. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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