货号	规格	价格	上海	北京	珠海	重庆	武汉
S89560-5mg买3赠1	99.10%	￥590.00 S89560-5mg ￥590.00 现货（买3赠1）	6 6	-	-	-	-
S89560-10mg	99.10%	￥980.00 S89560-10mg ￥980.00 现货	6 6	-	-	-	-
S89560-25mg	99.10%	￥1990.00 S89560-25mg ￥1990.00 现货	6 6	-	-	-	-
S89560-100mg	≥98%	￥4290.00 S89560-100mg ￥4290.00 2-3天	0 货期：2-3天	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

S-14506 hydrochloride is a potent 5-HT1A agonist, as well as 5-HT2A/2C antagonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent

靶点：

5-HT Receptor;Dopamine Receptor;5-HTReceptor

体外研究：

S-14506 hydrochloride 作为5-HT1A受体激动剂，似乎是 G(i) 蛋白依赖性。 S-14506 hydrochloride (0.1 nM-100 μM；10 min) 在百日咳毒素处理的 HeLa 细胞中，对 5-HT 受体的 G 蛋白解偶联状态显示出高亲和力

体内研究：

S-14506 hydrochloride (0.2-3.38 mg/kg；IP；单剂量) 剂量依赖性拮抗 Apomorphine (0.75 mg/kg, s.c) 诱导的小鼠刻板攀登和嗅探。S-14506 hydrochloride 阻断多巴胺D2受体显示多巴胺拮抗剂特性。 S-14506 hydrochloride (0.63 mg/kg；SC；单剂量) 在大鼠强迫游泳试验中有活性。它能诱导大鼠一动不动。 Animal Model: Male swiss albino mice (25-30 g) and male Wistar rats (170-230 g) Dosage: 0.2 mg/kg, 0.8 mg/kg, 3.2 mg/kg, 3.8 mg/kg Administration: IP; single dose, 30 min before test Result: Inhibited stereotyped climbing and sniffing behaviours induced by dopamine agonists in mice and on spontaneous behaviours. Animal Model: Male Wistar rats (200-220 g) Dosage: 0.01 mg/kg, 0.63 mg/kg Administration: SC; and gave antagonist 30 min after agonist Result: Induced a dose-dependent imobility in rats.

参考文献：

1. Protais P, et al. Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents. Eur J Pharmacol. 1994 Dec 12;271(1):167-77. 2. Francis C. Colpaert, et al. S 14506: A novel, potent, high-efficacy 5-HT1A agonist and potential anxiolytic agent. 1992, 21-48. 3. Schreiber R, et al. The potent activity of the 5-HT1A receptor agonists, S 14506 and S 14671, in the rat forced swim test is blocked by novel 5-HT1A receptor antagonists. Eur J Pharmacol. 1994 Dec 27;271(2-3):537-41. 4. Assié MB, et al. Correlation between low/high affinity ratios for 5-HT(1A) receptors and intrinsic activity. Eur J Pharmacol. 1999 Dec 10;386(1):97-103.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.253 ml	11.263 ml	22.525 ml
5 mM	0.451 ml	2.253 ml	4.505 ml
10 mM	0.225 ml	1.126 ml	2.253 ml
50 mM	0.045 ml	0.225 ml	0.451 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

S14506 HCl

4-Fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]benzamide hydrochloride

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)