| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89621-5mg买3赠1 |
98.30% | ￥990.00 |
5 | - | - | - | - |
|
S89621-10mg促销 |
98.30% | ￥1680.00 ￥1340.00 |
5 | - | - | - | - |
|
S89621-25mg促销 |
98.30% | ￥3100.00 ￥2480.00 |
5 | - | - | - | - |
|
S89621-100mg促销 |
98.30% | ￥9500.00 ￥7600.00 |
2 | - | - | - | - |
|
| 产品描述： | ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 8.4 μM (EPAC2);EPAC1;cAMP | ||||||||||||||||||||
| 体外研究： | Exchange proteins directly activated by cAMP (EPAC) are a family of guanine nucleotide exchange factors that regulate a wide variety of intracellular processes in response to second messenger cAMP. ESI-08 at 25 μM has been found not to alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely | ||||||||||||||||||||
| 参考文献： | 1. Chen H, Tsalkova T, Mei FC, Hu Y, Cheng X, Zhou J. 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorg Med Chem Lett. 2012;22(12):4038-4043. doi:10.1016/j.bmcl.2012.04.082 | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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