货号	规格	价格	上海	北京	珠海	重庆	武汉
S89673-5mg买3赠1	99.80%	￥450.00 S89673-5mg ￥450.00 现货（买3赠1）	3 3	-	-	-	-
S89673-10mg买3赠1	99.80%	￥750.00 S89673-10mg ￥750.00 现货（买3赠1）	5 5	-	-	-	-
S89673-25mg买3赠1	99.80%	￥1500.00 S89673-25mg ￥1500.00 现货（买3赠1）	5 5	-	-	-	-
S89673-100mg买3赠1	99.80%	￥3370.00 S89673-100mg ￥3370.00 现货（买3赠1）	3 3	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

NFATc1-IN-1 (compound A04) is a potent inhibitor of RANKL-induced osteoclast formation, with an IC50 of 1.57 μM. NFATc1-IN-1 shows anti-osteoclastogenic effects through reducing the RANKL-induced nuclear translocation of NFATc1. NFATc1-IN-1 can be used for osteoclastic diseases research

靶点：

Nuclear Factor of activated T Cells (NFAT);RANKL/RANK

体外研究：

NFATc1-IN-1 (compound A04) (0-2.5 μM, 4 days) exhibits potent inhibitory activities on osteoclast formation and function, which eventually translates into decreased bone resorption. NFATc1-IN-1 (1.5-2.5 μM, 24 h) blocks NFATc1 nuclear translocation and decreases the level of NFATc1. Cell Viability Assay Cell Line: Osteoclast precursor RAW 264.7 cells Concentration: 0, 0.5, 1.0, 1.5, 2.0 and 2.5 μM Incubation Time: 4 days Result: Markedly reduced the number and size of red TRAP-positive multinucleated osteoclasts at concentrations of 1.5, 2.0, and 2.5 μM. Significantly inhibited formation of osteoclasts in a dose-dependent manner (at 1.5, 2.0 and 2.5 μM), while showing no cytotoxic effects towards osteoclast precursor cells at concentrations of as high as 2.5 μM. Immunofluorescence Cell Line: RAW264.7 cells Concentration: 1.5 or 2.5 μM Incubation Time: 24 h Result: Blocked NFATc1 nuclear translocation and decreased the level of NFATc1.

参考文献：

1. Chen CL, et al. Design, synthesis and SARs of novel salicylanilides as potent inhibitors of RANKL-induced osteoclastogenesis and bone resorption. Eur J Med Chem. 2016 Jul 19;117:70-84.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.666 ml	13.329 ml	26.659 ml
5 mM	0.533 ml	2.666 ml	5.332 ml
10 mM	0.267 ml	1.333 ml	2.666 ml
50 mM	0.053 ml	0.267 ml	0.533 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置