| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89675-5mg促销 |
99.70% | ￥1300.00 ￥1040.00 |
5 | - | - | - | - |
|
S89675-10mg促销 |
99.70% | ￥2000.00 ￥1600.00 |
5 | - | - | - | - |
|
S89675-25mg促销 |
99.70% | ￥3680.00 ￥2940.00 |
5 | - | - | - | - |
|
S89675-100mg促销 |
99.70% | ￥8400.00 ￥6720.00 |
3 | - | - | - | - |
|
| 产品描述： | MitoBloCK-10 (MB-10) is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity. MitoBloCK-10 (MB-10) inhibits Tim44 (C-terminal domain) binding to the precursor and to Hsp70 | ||||||||||||||||||||
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| 靶点： | HSP | ||||||||||||||||||||
| 体外研究： | MB-10 (100 μM) 是蛋白质输入线粒体的潜在衰减剂。 MB-10 抑制使用 TIM23 输入通路的底物输入。 MB-10 (0-100 μM) 抑制蛋白质输入哺乳动物线粒体。 Cell Viability Assay Cell Line: A plasmid expressing Su9-Ura3-myc was integrated at the LEU2 locus in WT and tim23-2 strains. Concentration: 100 μM. Incubation Time: 30 min. Result: WT strain expressing Su9-Ura3 failed to grow, whereas the tim23-2 mutant expressing Su9-Ura3 grew much faster. The strains grew at a similar rate when the medium was supplemented with uracil. Cell Viability Assay Cell Line: HeLa cells. Concentration: 0-100 μM. Incubation Time: 24 h. Result: Inhibited HeLa cells vibility, with an IC50 of 17.2 μM. | ||||||||||||||||||||
| 参考文献： | 1. Non Miyata, et al. Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44. J Biol Chem. 2017 Mar 31;292(13):5429-5442. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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