货号	规格	价格	上海	北京	珠海	重庆	武汉
S89699-5mg买3赠1	98.45%	￥500.00 S89699-5mg ￥500.00 现货（买3赠1）	208 >10	-	-	-	-
S89699-10mg买3赠1	98.45%	￥800.00 S89699-10mg ￥800.00 现货（买3赠1）	106 2 >10	2	-	-	-
S89699-25mg买3赠1	98.45%	￥1500.00 S89699-25mg ￥1500.00 现货（买3赠1）	47 2 >10	2	-	-	-
S89699-100mg买3赠1	98.45%	￥3500.00 S89699-100mg ￥3500.00 现货（买3赠1）	16 2 >10	2	-	-	-

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产品描述：

MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models

靶点：

STING

体内研究：

MSA-2 dosed via either PO or SC regimens achieved comparable exposure in both tumor and plasma. MSA-2 also exhibits dose-dependent antitumor activity when administered by IT, SC, or PO routes, and dosing regimens were identified that induced complete tumor regressions in 80 to 100% of treated animals. MSA-2 (PO: 60 mg/kg or SC: 50 mg/kg; single dose) that effectively inhibits tumor growth induced substantial elevations of IFN-β, interleukin-6 (IL-6), and TNF-α in tumor. Animal Model: MC38 tumor-bearing C57BL6 mice Dosage: 60 mg/kg Administration: P.o. ; s.c (50 mg/kg); single dose Result: PO or SC doses of MSA-2 that effectively inhibited tumor growth induced substantial elevations of IFN-β, interleukin-6 (IL-6), and TNF-α in tumor.

参考文献：

1. Pan BS, et al. An orally available non-nucleotide STING agonist with antitumor activity. Science. 2020;369(6506):eaba6098.

2. Liu J, et al. Identification of MSA-2: An oral antitumor non-nucleotide STING agonist. Signal Transduct Target Ther. 2021;6(1):18. Published 2021 Jan 12.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.398 ml	16.988 ml	33.977 ml
5 mM	0.68 ml	3.398 ml	6.795 ml
10 mM	0.34 ml	1.699 ml	3.398 ml
50 mM	0.068 ml	0.34 ml	0.68 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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