货号	规格	价格	上海	北京	珠海	重庆	武汉
S89768-5mg买3赠1	99.20%	￥470.00 S89768-5mg ￥470.00 现货（买3赠1）	5 5	-	-	-	-
S89768-10mg促销	99.20%	￥710.00 ￥568.00 S89768-10mg ￥568.00 现货	6 6	-	-	-	-
S89768-25mg促销	99.20%	￥1060.00 ￥848.00 S89768-25mg ￥848.00 现货	5 5	-	-	-	-
S89768-100mg促销	≥98%	￥3080.00 ￥2770.00 S89768-100mg ￥2770.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity sodium glucose cotransporter (SGLT2) inhibitor with Ki values of 1.95 μM, 2.14 μM, 43.1 μM, 8.57 μM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate is a proagent based on benzylpyrazole glucoside and is metabolized to its active form, Remogliflozin, in the body. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models

靶点：

hSGLT2:1.95 μM (Ki);rSGLT2:2.14 μM (Ki);hSGLT1:43.1 μM (Ki);rSGLT1:8.57 μM (Ki);SGLT

体内研究：

Remogliflozin etabonate (GSK189075; 10 or 30 mg/kg; orally; twice daily for 6 weeks) significantly reduced both the FPG and GHb levels in a dosedependent manner. Remogliflozin etabonate (3, 10, 30 mg/kg; orally) increases urinary glucose excretion in a dose-dependent manner. Remogliflozin etabonate dose-dependently inhibits the increase in plasma glucose after glucose loading and decreases the plasma insulin in normal rats. Remogliflozin etabonate (1-10 mg/kg; orally) decreases the blood glucose and reduces the AUC0–6 h for blood glucose in a dose-dependent manner. Remogliflozin etabonate (high-fat diet containing 0.01, 0.03, or 0.1% remogliflozin etabonate for 8 weeks) reduces the levels of plasma glucose, plasma insulin, and GHb in a dose-dependent manner, and it suppresses the development of hypertriglyceridemia in male GK rats (6 weeks of age). Animal Model: db/db mice at the age of 8 weeks Dosage: 10 or 30 mg/kg Administration: Orally; twice daily for 6 weeks Result: Significantly reduced both the fasting plasma glucose (FPG) and glycated hemoglobin (GHb) levels in a dosedependent manner.Reduced both urine volume and urinary glucose excretion with ameliorated the hyperglycemia.

参考文献：

1. Yoshikazu Fujimori, et al. Remogliflozin Etabonate, in a Novel Category of Selective Low-Affinity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models. J Pharmacol Exp Ther. 2008 Oct;327(1):268-76.

溶解性：

soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.914 ml	9.568 ml	19.136 ml
5 mM	0.383 ml	1.914 ml	3.827 ml
10 mM	0.191 ml	0.957 ml	1.914 ml
50 mM	0.038 ml	0.191 ml	0.383 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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