货号	规格	价格	上海	北京	珠海	重庆	武汉
S89804-5mg买3赠1	98.70%	￥2120.00 S89804-5mg ￥2120.00 现货（买3赠1）	5 5	-	-	-	-
S89804-10mg买3赠1	98.70%	￥3600.00 S89804-10mg ￥3600.00 现货（买3赠1）	7 7	-	-	-	-
S89804-25mg	98.70%	￥6270.00 S89804-25mg ￥6270.00 现货	5 5	-	-	-	-

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产品描述：

Brilaroxazine (RP5603) is a potent and orally active multimodal dopamine (DA)/serotonin (5-HT) modulator. Brilaroxazine is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki=1.5 nM) and 5-HT2A (Ki=2.5 nM), and has antagonist activity at 5-HT2B (Ki=0.19 nM), and 5-HT7 (Ki=2.7 nM) receptors. Brilaroxazine is an atypical antipsychotic agent, and has the potential to improve cognitive impairments in neuropsychiatric and neurological diseases in vivo

靶点：

5-HT1A Receptor:1.5 nM (Ki);5-HT2A Receptor:2.5 nM (Ki);5-HT2B Receptor:0.19 nM (Ki);5-HT7 Receptor:2.7 nM (Ki);D2 Receptor;D3 Receptor;D4 Receptor;DopamineReceptor; 5-HTReceptor

体内研究：

Brilaroxazine (oral gavage; 10 mg/kg; twice daily; 28 days) limits the functional and structural effects of pulmonary arterial hypertension (PAH), with significant improvements in pulmonary hemodynamics, right ventricular (RV) hypertrophy, SO2, and pulmonary blood vessel structural changes. Animal Model: SD-rats Dosage: 10 mg/kg Administration: Oral gavage; twice daily; 28 days Result: Had the efficacy in PAH, and mitigated the functional and structural effects of MCT-induced PAH.

参考文献：

1. Reviva Pharmaceuticals Reports RP5063 Positive Efficacy Results for Memory Deficits 2. Bhat L, et al. Evaluation of the effects of RP5063, a novel, multimodal, serotonin receptor modulator, as single-agent therapy and co-administrated with sildenafil, bosentan, and treprostinil in a monocrotaline-induced pulmonary arterial hypertension rat 3. L. Bhat,et al. Rp5063 Prevents Monocrotaline Induced Pulmonary Arterial Hypertension In Rats.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.22 ml	11.102 ml	22.204 ml
5 mM	0.444 ml	2.22 ml	4.441 ml
10 mM	0.222 ml	1.11 ml	2.22 ml
50 mM	0.044 ml	0.222 ml	0.444 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

RP-5063