| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89968-5mg买3赠1 |
99.80% | ￥290.00 |
5 | - | - | - | - |
|
S89968-10mg买3赠1 |
99.80% | ￥430.00 |
5 | - | - | - | - |
|
S89968-25mg促销 |
99.80% | ￥650.00 ￥520.00 |
4 | - | - | - | - |
|
S89968-100mg促销 |
99.80% | ￥1880.00 ￥1500.00 |
2 | - | - | - | - |
|
| 产品描述： | AMPC 是一种有效的 TFF3 抑制剂。在 TFF3 阳性的 CMS4 结直肠癌细胞中，AMPC 可抑制细胞增殖、存活、致瘤性和 CSC 样行为。AMPC 作为一种潜在的抗癌试剂，可以单独或和 5-FU 联合使用，用于癌症研究。 |
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| 体外研究： | AMPC decreases cell proliferation in CMS4 CRC cells, the IC50 values are 2.63 μM, 4.65 μM, and 69.69 μM, respectively in SW620 (high TFF3 expression), Caco-2, SW480 cells (low TFF3 expression), respectively. AMPC (1-10 μM) significantly reduces the total cellular levels of TFF3 in SW620 and Caco2 cells in a dose dependent manner. AMPC induces apoptosis in a dose dependent manner by the inhibition of TFF3, it induces a decrease in the S-phase population and increases caspase3/7 activity compared with control cells. |
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| 体内研究： | AMPC (intraperitoneal injection; 40 mg/kg; once daily) leads to a significant reduction of tumour volume in AMPC-treated mice as compared to vehicle-treated mice from day 11 onward. AMPC results in larger areas of tumour necrosis and increased area of cells with apoptotic features in SW620 tumours. AMPC also significantly reduces tumour and serum TFF3 levels in vivo. | ||||||||||||||||||||
| 参考文献： | 1. Ru-Mei Chen, et al. Pharmacological Inhibition of TFF3 Enhances Sensitivity of CMS4 Colorectal Carcinoma to 5-Fluorouracil through Inhibition of p44/42 MAPK. Int J Mol Sci. 2019 Dec 9;20(24):6215 | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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