| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T19658-5mg促销 |
≥98%(HPLC) | ￥488.00 ￥439.00 |
10 | - | - | - | - |
|
T19658-10mg促销 |
≥98%(HPLC) | ￥899.00 ￥809.00 |
10 | - | - | - | - |
|
T19658-25mg促销 |
≥98%(HPLC) | ￥2080.00 ￥1870.00 |
2 | - | - | - | - |
|
T19658-50mg促销 |
≥98%(HPLC) | ￥3140.00 ￥2830.00 |
1 | - | - | - | - |
|
T19658-100mg促销 |
≥98%(HPLC) | ￥5030.00 ￥4530.00 |
货期：3-5天 | - | - | - | - |
|
| 靶点： | IC50: 10.7 μM (Epac1), 66 μM (Epac2(B)) | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 体内研究： | CE3F4 (1-3 mg/kg；通过颈内静脉导管) 抑制心房颤动 (AF)，CE3F4 (3 mg/kg；静脉注射) 抑制室性心律失常。 CE3F4 (10 mg/kg；iv) 改善小鼠心肌梗死后的心功能。 |
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| 参考文献： | 1. Courilleau D, et al. The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1). Biochem Biophys Res Commun. 2013 Oct 25;440(3):443-8. 2. Courilleau D, et al. Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. J Biol Chem. 2012 Dec 28;287(53):44192-202. 3. Pratt EP, et al. Ca2+ influx through L-type Ca2+ channels and Ca2+-induced Ca2+ release regulate cAMP accumulation and Epac1-dependent ERK 1/2 activation in INS-1 cells. Mol Cell Endocrinol. 2016 Jan 5;419:60-71. 4. Prajapati R, et al. Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice. Circ J. 2019;83(2):295-303. 5. Abstract 17548: Inhibition of Exchange Protein 1 Directly Activated by cAMP (Epac1) is Cardioprotective Against Ischemia-reperfusion Injury |
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| 保存条件： | -20℃;充氩 | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京