| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T20219-5mg促销 |
≥99% | ￥1470.00 ￥1320.00 |
3 | - | - | - | - |
|
T20219-10mg促销 |
≥99% | ￥1850.00 ￥1660.00 |
1 | - | - | - | - |
|
T20219-25mg促销 |
≥99% | ￥3610.00 ￥3250.00 |
1 | - | - | - | - |
|
T20219-50mg促销 |
≥99% | ￥5740.00 ￥5170.00 |
2 | - | - | - | - |
|
T20219-100mg促销 |
≥99% | ￥9260.00 ￥8340.00 |
1 | - | - | - | - |
|
| 产品描述： | (S)-3,4-DCPG HCl is a selective metabotropic glutamate receptor 8a (mGluR8a) agonist that has an effect on human mGluR8-expressing AV12-664 cells with an EC50 of 31 nM | ||||||||||||||||||||
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| 靶点： | hmGluR8a:31 nM (EC50);GluR | ||||||||||||||||||||
| 体内研究： | (S)-3,4-DCPG (3-100 mg/kg, i.p.) maked c-Fos as an indicator of neuronal activity in specific brain regions 2 hours after systemic administration. In wild-type mice, (S)-3,4-DCPG (100 mg/kg) significantly increased c-Fos expression in several stress-related brain regions: paraventricular nucleus of the hypothalamus, central nucleus of the amygdala, lateral parabrachial nucleus and locus coeruleus | ||||||||||||||||||||
| 参考文献： | 1. Thomas NK, et al. (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 2001 ; 40(3):311-318. 2. Linden AM, et al. Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice. Neuropharmacology. 2003 ; 45(4):473-483. 3. Jiang FL, et al. Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus. Epilepsia. 2007 ; 48(4):783-792. 4. Marabese I, et al. Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. Neuropharmacology. 2007 ; 52(2):253-262. 5. Stachowicz K, et al. Lack of the antianxiety-like effect of (S)-3,4-DCPG, an mGlu8 receptor agonist, after central administration in rats. Pharmacol Rep. 2005 ; 57(6):856-860. 6. Johnson KA, et al. The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease. Neuropharmacology. 2013 ; 66:187-195. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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