| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T23381-5mg促销 |
≥98% | ￥1020.00 ￥810.00 |
3 | - | - | - | - |
|
T23381-10mg促销 |
≥98% | ￥1850.00 ￥1480.00 |
8 | - | - | - | - |
|
T23381-25mg促销 |
≥98% | ￥3640.00 ￥2910.00 |
3 | - | - | - | - |
|
T23381-50mg促销 |
≥98% | ￥5930.00 ￥4740.00 |
4 | - | - | - | - |
|
T23381-100mg促销 |
≥98% | ￥9260.00 ￥7410.00 |
1 | - | - | - | - |
|
| 产品描述： | LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity. | ||||||||||||||||||||
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| 靶点： | PRMT5;HistoneMethyltransferase | ||||||||||||||||||||
| 体外研究： | LLY-283 is a potent, oral and selective arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM in vitro and 25 nM in cells, as well as a Kd of 6 nM for PRMT5:MEP50 complex in vitro; LLY-283 inhibits the proliferation of A375 cell with an IC50 of 46 nM. | ||||||||||||||||||||
| 体内研究： | LLY-283 (20 mg/kg; p.o., QD (once a day)) causes a significant inhibition on tumor growth in mice bearing A375 cells after treatment for 28 days. | ||||||||||||||||||||
| 参考文献： | 1. Zahid Q. Bonday, et al. LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Med. Chem. Lett., 2018, 9 (7), pp 612-617. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、H2O | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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