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LLY-283

    
≥98%

(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol

源叶(MedMol)
T23381 一键复制产品信息
2040291-27-6
C17H18N4O4
342.34922
LLY-283; LLY 283; LLY283; LM-5179; LM 5179; LM5179.
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
T23381-5mg促销
≥98%

¥1020.00 ¥810.00

3 - - - -
T23381-10mg促销
≥98%

¥1850.00 ¥1480.00

8 - - - -
T23381-25mg促销
≥98%

¥3640.00 ¥2910.00

3 - - - -
T23381-50mg促销
≥98%

¥5930.00 ¥4740.00

4 - - - -
T23381-100mg促销
≥98%

¥9260.00 ¥7410.00

1 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity.
靶点: PRMT5;HistoneMethyltransferase
体外研究: LLY-283 is a potent, oral and selective arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM in vitro and 25 nM in cells, as well as a Kd of 6 nM for PRMT5:MEP50 complex in vitro; LLY-283 inhibits the proliferation of A375 cell with an IC50 of 46 nM.
体内研究: LLY-283 (20 mg/kg; p.o., QD (once a day)) causes a significant inhibition on tumor growth in mice bearing A375 cells after treatment for 28 days.
参考文献: 1. Zahid Q. Bonday, et al. LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Med. Chem. Lett., 2018, 9 (7), pp 612-617.
溶解性: Soluble  in  DMSO、H2O
保存条件: -20°C
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.921 ml 14.605 ml 29.21 ml
5 mM 0.584 ml 2.921 ml 5.842 ml
10 mM 0.292 ml 1.46 ml 2.921 ml
50 mM 0.058 ml 0.292 ml 0.584 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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