货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T23412-5mg	98%	￥1000.00 T23412-5mg ￥1000.00 2-4周	0 货期：2-4周	-	-	-	-
T23412-10mg	98%	￥1460.00 T23412-10mg ￥1460.00 2-4周	0 货期：2-4周	-	-	-	-

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体内研究：

LY-2584702 demonstrates significant single-agent efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models at two dose levels of 2.5 mg/kg twice daily (BID) and 12.5 mg/kg BID. LY-2584702 demonstrates statistically significant tumour growth reduction at TMED50 (threshold minimum effective dose 50%) (2.3 mg/kg) and TMED90 (10 mg/kg) in the HCT116 colon carcinoma xenograft model. To examine the role of S6K in vivo, EOMA cells expressing shAkt3 are implanted in nu/nu mice, then treated for 14 days with LY-2584702 or Rapamycin. Analysis of tumors removed after 14 days shows that LY-2584702 inhibits S6 phosphorylation almost as effectively as Rapamycin. Loss of Akt3 increases tumor growth as compared with pLKO. LY-2584702 treatment alone does not significantly affect the growth of pLKO tumors. However, LY-2584702 significantly reduces the growth of tumors with shAkt3.

溶解性：

10 mM in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.075 ml	10.376 ml	20.752 ml
5 mM	0.415 ml	2.075 ml	4.15 ml
10 mM	0.208 ml	1.038 ml	2.075 ml
50 mM	0.042 ml	0.208 ml	0.415 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

LY-2584702 (hydrochloride)