| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T24307-5mg促销 |
≥98%(HPLC) | ￥700.00 ￥630.00 |
10 | - | - | - | - |
|
T24307-10mg促销 |
≥98%(HPLC) | ￥950.00 ￥855.00 |
10 | - | - | - | - |
|
T24307-25mg促销 |
≥98%(HPLC) | ￥1590.00 ￥1430.00 |
6 | - | - | - | - |
|
T24307-50mg促销 |
≥98%(HPLC) | ￥2240.00 ￥2010.00 |
6 | - | - | - | - |
|
T24307-100mg促销 |
≥98%(HPLC) | ￥3860.00 ￥3470.00 |
2 | - | - | - | - |
|
| 靶点： | IC50: 0.4 μM (vasopressin V1);Ki: 0.14 μM (vasopressin V1) | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 体内研究： | Fuscoside (OPC-21268) competitively and specifically antagonizes pressor responses to AVP in vivo. Oral administration of Fuscoside (OPC-21268) (10 mg/kg) inhibits the vasoconstriction induced by exogenous AVP in a dose- and time-dependent manner and the effect lasts for more than 8 hours at 30 mg/kg. Fuscoside (OPC-21268) predominantly exerts a protective effect in areas where the maximum amount of blood-brain barrier breakdown occurs, and it is effective in the treatment of cold-induced vasogenic brain edema. Fuscoside (OPC-21268) treatment at the dosages of 200 and 300 mg/kg significantly reduces brain water content in both hemispheres. Swelling of the traumatized hemispheres is also significantly reduced at 200 and 300 mg/kg dosages. | ||||||||||||||||||||
| 参考文献： | 1. Yamamura Y, et al. OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist. Science. 1991 Apr 26;252(5005):572-4. 2. Bemana I, et al. Treatment of brain edema with a nonpeptide arginine vasopressin V1 receptor antagonist OPC-21268 in rats. Neurosurgery. 1999 Jan;44(1):148-54. |
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| 溶解性： | DMSO: ≥20mg/mL | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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