| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T25582-1mg促销 |
98% | ￥212.00 ￥190.00 |
8 | - | - | - | - |
|
T25582-5mg促销 |
98% | ￥799.00 ￥719.00 |
8 | - | - | - | - |
|
T25582-10mg促销 |
98% | ￥1160.00 ￥1050.00 |
8 | - | - | - | - |
|
T25582-25mg促销 |
98% | ￥2310.00 ￥2080.00 |
9 | - | - | - | - |
|
T25582-50mg促销 |
98% | ￥3700.00 ￥3330.00 |
4 | - | - | - | - |
|
T25582-100mg促销 |
98% | ￥5840.00 ￥5250.00 |
4 | - | - | - | - |
|
T25582-250mg促销 |
98% | ￥12900.00 ￥11600.00 |
货期：3-5天 | - | - | - | - |
|
T25582-500mg促销 |
98% | ￥18500.00 ￥16600.00 |
2 | - | - | - | - |
|
| 产品描述： | Rilmenidine hemifumarate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine hemifumarate is an alpha 2-adrenoceptor agonist. Rilmenidine hemifumarate induces autophagy. Rilmenidine hemifumarate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine hemifumarate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Imidazoline Receptor;Adrenergic Receptor;Apoptosis;Autophagy;Apoptosis; ImidazolineReceptor | ||||||||||||||||||||
| 体外研究： | Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors. Rilmenidine (25-100 μM; 24 hours) inhibits K562 cell proliferation. Cell Viability Assay Cell Line: K562 cells Concentration: 25, 50, 100 μM Incubation Time: 24 hours Result: Dose-dependently inhibited K562 colony formation. | ||||||||||||||||||||
| 体内研究： | Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age. Rilmenidine decreases levels of mutant huntingtin. |
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| 参考文献： | 1. Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S. 2. Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180. 3. Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19(11):2144-2153. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、H2O | ||||||||||||||||||||
| 保存条件： | -20℃，密闭，干燥 | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京