货号	规格	价格	上海	北京	珠海	重庆	武汉
T26952-5mg买3赠1	99.10%	￥270.00 T26952-5mg ￥270.00 现货（买3赠1）	9 9	-	-	-	-
T26952-10mg买3赠1	99.10%	￥300.00 T26952-10mg ￥300.00 现货（买3赠1）	5 5	-	-	-	-
T26952-25mg买3赠1	99.10%	￥400.00 T26952-25mg ￥400.00 现货（买3赠1）	5 5	-	-	-	-
T26952-100mg促销	99.10%	￥720.00 ￥576.00 T26952-100mg ￥576.00 现货	3 3	-	-	-	-

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产品描述：

MS21570 is a selective GPR171 antagonist, with an IC50 of 220 nM.

靶点：

IC50: 220 nM (GPR171);GPR

体内研究：

MS21570 significantly attenuates this CNO-mediated increase in food intake. Interestingly, MS21570 causes a significant increase in center time compared to vehicle suggesting an effect on the anxiety-like behavior. Intra-BLA administration of MS21570 leads to an increase in open arm time on the elevated plus maze although there is no effect on locomotor activity during this test. Interestingly, when administered before and immediately following fear conditioning, MS21570 significantly attenuates freezing measured 24 hours later. Behavioral differences between systemic and intra-BLA administration of MS21570 could be due to the pharmacokinetic and pharmacodynamic properties of the drug. Further studies are needed to characterize the GPR171 antagonist

参考文献：

1. Bobeck EN, et al. The BigLEN-GPR171 Peptide Receptor System Within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning. Neuropsychopharmacology. 2017 Dec;42(13):2527-2536.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.213 ml	21.067 ml	42.134 ml
5 mM	0.843 ml	4.213 ml	8.427 ml
10 mM	0.421 ml	2.107 ml	4.213 ml
50 mM	0.084 ml	0.421 ml	0.843 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

5-(苄基硫代)-N-甲基-1,3,4-噻二唑-2-胺

5-(BENZYLTHIO)-N-METHYL-1,3,4-THIADIAZOL-2-AMINE

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)