货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T27088-1mg	98%	￥18300.00 T27088-1mg ￥18300.00 2-4周	0 货期：2-4周	-	-	-	-

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体内研究：

Treatment with a single local application of TAK-778/PLGA-MC (0.2 to 5 mg/site) results in a dose-dependent increase in the radio-opaque area formed in the defect. Histological studies show the defect area is occupied by a bony bridge and the newly-formed radio-opaque area corresponds to a calcified bone containing bone marrow cavities surrounded by thick osteoid seams with cuboidal osteoblasts. There is no significant difference in either of the indices between placebo- or TAK-778/PLGA-MC-treated skulls. Two months after the operation, the TAK-778/PLGA-MC pellets induce radiological osseous union across the defects. Oral treatment of OVX rats with TAK-778 causes a more pronounced increase in bone mineral density (BMD) of the lumbar vertebrae compare to vehicle controls.

参考文献：

1. Rosa AL, et al. TAK-778 enhances osteoblast differentiation of human bone marrow cells via an estrogen-receptor-dependent pathway. J Cell Biochem. 2004 Mar 1;91(4):749-55.
2. Notoya K, et al. Enhancement of osteogenesis in vitro and in vivo by a novel osteoblast differentiation promoting compound, TAK-778. J Pharmacol Exp Ther. 1999 Sep;290(3):1054-64.
3. Cai M, et al. TAK-778 induces osteogenesis in ovariectomized rats via an estrogen receptor-dependent pathway. J Bone Miner Metab. 2011 Mar;29(2):168-73.

保存条件：

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.978 ml	9.891 ml	19.782 ml
5 mM	0.396 ml	1.978 ml	3.956 ml
10 mM	0.198 ml	0.989 ml	1.978 ml
50 mM	0.04 ml	0.198 ml	0.396 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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计算重置

二乙基 4-((6R,8S)-8-甲基-9-氧亚基-5,6,8,9-四氢噻庚英并[4,5:4,5]苯并[1,2-D][1,3]二噁戊环-6-碳杂草酰氨基)苯甲基膦酸基酯

diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)