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T-3775440 HCl

    
≥99%

T-3775440 HCl

源叶(MedMol)
T27100 一键复制产品信息
1422535-52-1
C18H23ClN4O
346.85
T-3775440 hydrochloride
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
T27100-2mg促销
≥99%

¥1000.00 ¥900.00

6 - - - -
T27100-5mg促销
≥99%

¥2000.00 ¥1800.00

8 - - - -
T27100-10mg促销
≥99%

¥3200.00 ¥2880.00

6 - - - -
T27100-25mg促销
≥99%

¥5000.00 ¥4500.00

7 - - - -
T27100-50mg促销
≥99%

¥7000.00 ¥6300.00

6 - - - -
T27100-100mg促销
≥99%

¥9000.00 ¥8100.00

3 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
体内研究: T-3775440 upregulates CD86 mRNA expression in tumor xenografts of HEL92.1.7 cells in a dose-dependent manner following the oral administration of single doses ranging from 3 to 30 mg/kg. To investigate target engagement of this compound in tumors, PI16 expression levels is tested as a direct biomarker. As expected, PI16 suppression is dramatically reversed by T-3775440 treatment. In a TF-1a (AEL) tumor xenograft model, T-3775440 exhibits significant antitumor effects, with 15-day T/C values of 15.6% and <0% at doses of 20 and 40 mg/kg, respectively. T-3775440 also exhibits potent antitumor effects in an additional AEL model of HEL 92.1.7 and an AMKL model of CMK11-5, leading to nearly complete tumor growth suppression during the dosing period. It is found that in mice, T-3775440 treatment results in a transient reduction in platelets, followed by a significant rebound; this is considered a mechanism-based adverse effect of LSD1 inhibition. On a dosing schedule comprising 5 days on/2 days off, a statistically significant difference in body weight is observed between vehicle- and T-3775440-treated tumor xenograft model mice at higher doses. However, efficacious T-3775440 doses are tolerated in all subcutaneous tumor xenograft models.
参考文献: 1. Ishikawa Y, et al. A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells. Mol Cancer Ther. 2017 Feb;16(2):273-284.
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.883 ml 14.415 ml 28.831 ml
5 mM 0.577 ml 2.883 ml 5.766 ml
10 mM 0.288 ml 1.442 ml 2.883 ml
50 mM 0.058 ml 0.288 ml 0.577 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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