| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T27100-2mg促销 |
≥99% | ￥1000.00 ￥900.00 |
6 | - | - | - | - |
|
T27100-5mg促销 |
≥99% | ￥2000.00 ￥1800.00 |
8 | - | - | - | - |
|
T27100-10mg促销 |
≥99% | ￥3200.00 ￥2880.00 |
6 | - | - | - | - |
|
T27100-25mg促销 |
≥99% | ￥5000.00 ￥4500.00 |
7 | - | - | - | - |
|
T27100-50mg促销 |
≥99% | ￥7000.00 ￥6300.00 |
6 | - | - | - | - |
|
T27100-100mg促销 |
≥99% | ￥9000.00 ￥8100.00 |
3 | - | - | - | - |
|
| 体内研究： | T-3775440 upregulates CD86 mRNA expression in tumor xenografts of HEL92.1.7 cells in a dose-dependent manner following the oral administration of single doses ranging from 3 to 30 mg/kg. To investigate target engagement of this compound in tumors, PI16 expression levels is tested as a direct biomarker. As expected, PI16 suppression is dramatically reversed by T-3775440 treatment. In a TF-1a (AEL) tumor xenograft model, T-3775440 exhibits significant antitumor effects, with 15-day T/C values of 15.6% and <0% at doses of 20 and 40 mg/kg, respectively. T-3775440 also exhibits potent antitumor effects in an additional AEL model of HEL 92.1.7 and an AMKL model of CMK11-5, leading to nearly complete tumor growth suppression during the dosing period. It is found that in mice, T-3775440 treatment results in a transient reduction in platelets, followed by a significant rebound; this is considered a mechanism-based adverse effect of LSD1 inhibition. On a dosing schedule comprising 5 days on/2 days off, a statistically significant difference in body weight is observed between vehicle- and T-3775440-treated tumor xenograft model mice at higher doses. However, efficacious T-3775440 doses are tolerated in all subcutaneous tumor xenograft models. | ||||||||||||||||||||
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| 参考文献： | 1. Ishikawa Y, et al. A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells. Mol Cancer Ther. 2017 Feb;16(2):273-284. | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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