货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T27133-5mg	98%	￥2490.00 T27133-5mg ￥2490.00 2-4周	0 货期：2-4周	-	-	-	-
T27133-10mg	98%	￥4310.00 T27133-10mg ￥4310.00 2-4周	0 货期：2-4周	-	-	-	-

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体内研究：

TG 100801 exhibits excellent ocular pharmacokinetics and poor systemic circulation and shows good efficacy in the laser induced choroidal neovascularization model. A concentration of 23.4 μM (Cmax) of TG 100572 is reached in 30 min (Tmax)=0.5 h) in the choroid and the sclera. However, the levels of TG 100572 in the retina are relatively low. The half-life of TG 100572 in ocular tissues is very short; hence, the compound is administered topically minimum t.i.d. to maintain appropriate drug levels in the eye. The maximum concentration one can achieve in formulations using TG 100572 is 0.7% w/v. TG 100801 nor TG100572 are detectable in plasma following topical delivery of TG 100801, and adverse safety signals (such as weight loss) are not observed even with prolonged dosing schedules. Topical TG 100801 significantly suppresses laser-induced choroidal neovascularlization in mice, and reduces fluorescein leakage from the vasculature and retinal thickening measured by optical coherence tomography in a rat model or retinal vein occlusion.Systemic delivery of TG 100572 in a murine model of laser-induced choroidal neovascularization (CNV) causes significant suppression of CNV, but with an associated weight loss suggestive of systemic toxicity.

保存条件：

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.622 ml	8.11 ml	16.22 ml
5 mM	0.324 ml	1.622 ml	3.244 ml
10 mM	0.162 ml	0.811 ml	1.622 ml
50 mM	0.032 ml	0.162 ml	0.324 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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体积

分子摩尔量

计算重置

TG 100801 (Hydrochloride)