货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T27417-1mg买3赠1	99.60%	￥230.00 T27417-1mg ￥230.00 现货（买3赠1）	204 >10	-	-	-	-
T27417-5mg买3赠1	99.60%	￥480.00 T27417-5mg ￥480.00 现货（买3赠1）	47 >10	-	-	-	-

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靶点：

IC50: 44 nM (ACAT in rabbit liver microsomes)

体内研究：

YM17E (3, 10 and 30 mg/kg per day, p.o.) decreases total cholesterol, cholesteryl ester and non-HDL cholesterol in a dose-dependent manner. Total cholesterol and cholesteryl ester levels in liver do not decrease significantly after intravenous administration of YM17E, but do decrease significantly and in a dose-dependent manner after oral administration. YM17E (3, 5, 10 mg/kg, i.v.) significantly inhibits hepatic ACAT activities in a dose-dependent manner. YM17E produces a significant increase in 125I-LDL clearance in atherogenic diet-fed rats after both oral and intravenous administration. YM17E inhibits production of [14C]cholesteryloleate from [14C]oleoyl CoA in a dose-dependent manner in both liver and intestinal microsomes used as enzyme sources.

参考文献：

1. Uchida T, et al. Relationship between bioavailability and hypocholesterolemic activity of YM17E, an inhibitor of ACAT, in cholesterol-fed rats. Atherosclerosis. 1998 Mar;137(1):97-106.
2. Kashiwa M, et al. Pharmacological properties of YM17E, an acyl-CoA:cholesterol acyltransferase inhibitor, and diarrheal effect in beagle dogs. Jpn J Pharmacol. 1997 Jan;73(1):41-50.

溶解性：

DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.532 ml	7.658 ml	15.316 ml
5 mM	0.306 ml	1.532 ml	3.063 ml
10 mM	0.153 ml	0.766 ml	1.532 ml
50 mM	0.031 ml	0.153 ml	0.306 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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