| 产品描述： | Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity |
| 靶点： |
Human Endogenous Metabolite |
| 体内研究： |
Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice) |
| 参考文献： |
1. Keshava C, et al. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res. 1998 Feb 2;397(2):221-8. 2. Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44. |
| 溶解性： |
H2O : 10 mg/mL (16.62 mM; Need ultrasonic) DMSO : 1 mg/mL (1.66 mM; ultrasonic and warming and heat to 80°C) |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.955 ml |
9.775 ml |
19.55 ml |
| 5 mM |
0.391 ml |
1.955 ml |
3.91 ml |
| 10 mM |
0.196 ml |
0.978 ml |
1.955 ml |
| 50 mM |
0.039 ml |
0.196 ml |
0.391 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京