| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T28106-1ml |
10mM in DMSO | ￥200.00 |
货期：3-5天 | - | - | - | - |
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| 产品描述： | VP-4604 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. VP-4604 exhibits significant microbial growth inhibition toward Staphylococcus aureus (ATCC 43300) with MIC of 4-8 µg/mL. VP-4604 inhibits the growth of methicillin‐resistant Staphylococcus aureus with growth inhibition >95% | ||||||||||||||||||||
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| 靶点： | Bacterial;Antibiotic | ||||||||||||||||||||
| 体外研究： | VP-4604 (2.5 mM, 18 hours) inhibits drug-resistant S. aureus and P. aeruginosa with growth inhibiton (%) GI >95%. VP-4604 shows low cytotoxicity with a CC50 value >118.4 mM towards HEK-293 (human embryonic kidney) ATCC CRL‐1573 and an HC10 vaule >118.4 μM towards RBC (human red blood cells). VP-4604 (2.5 mM) is tolerated by mammalian cells (HaCaT, lymphocytes) with the inhibition growth (%) of 44.1% and >50%, respectively. Cell Proliferation Assay Cell Line: S. aureus ATCC25923, P. aeruginosa ATCC9027 Concentration: 0.625 mM, 1.25 mM, 2.5 mM Incubation Time: 18 hours Result: Showed antibacterial effect. Cell Cytotoxicity Assay Cell Line: HaCaT line (human keratinocytes), lymphocytes (from healthy adult human peripheral blood) Concentration: 0, 1, 10, 100, 1000, 2500 μM Incubation Time: 48 or 72 hours Result: Showed low toxicity towards mammalian cells. | ||||||||||||||||||||
| 参考文献： | 1. Vitalii Palchykov, et al. Antimicrobial action of arylsulfonamides bearing (aza)norbornane and related motifs: evaluation of new promising anti-MRSA agents. Medicinal Chemistry Research. 2022. 31: 284-292. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -80℃（运输条件：冰袋低温运输） | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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